Health Sector
Medical
Mirasol Pathogen Reduction Technology

The Mirasol Pathogen Reduction Technology (PRT)  System renders a broad range of disease-causing viruses, bacteria and parasites less pathogenic, and inactivates residual white blood cells found in blood components.
Built for efficiency and ease of use, the novel Mirasol PRT system helps improve the safety of the blood supply by reducing the infectious levels of disease-causing agents in platelets and plasma while still maintaining quality blood components.

The Mirasol PRT system is:
• An innovative, proactive approach to addressing existing and emerging safety issues
• The only device that uses riboflavin (vitamin B2), a naturally ocurring, non-toxic compound, combined with ultraviolet light, to provide effective pathogen reduction and white cell inactivation
• A single platform capable of treating platelets and plasma using the same compound and light delivery system
• Versatile technology that is easy to learn and use

The Mirasol PRT system delivers: 
• An extra measure of safety in the face of emerging infectious diseases
• Reduced risk from screened and unscreened pathogens and white blood cells
• An effective alternative to bacterial screening of platelets, with no delay in product release
• Flexibility and ease of use for optimal operational efficiency
• Accurate reporting and traceability through fully integrated data capture

How it works

The Mirasol Pathogen Reduction Technology (PRT) System uses a combination of riboflavin (vitamin B2), a non-toxic, naturally occurring compound, and a specific spectrum of ultraviolet (UV) light to inactivate viruses, bacteria, parasites and white blood cells that may be present in collected blood products.

The Mirasol PRT system consists of three main components:
• A disposable kit — includes an illumination/storage bag and sterile riboflavin solution
• The Mirasol Illuminator — provides UV light and agitation for the Mirasol PRT process
• Mirasol® Manager software — integrates and manages data reporting and storage
During treatment, a blood product is mixed with the riboflavin solution and placed into the Illuminator where it is exposed to UV light for about five to ten minutes. There is no need to remove riboflavin or its photoproducts; after illumination, the treated products are ready for transfusion or placement into storage.

Mode of action:
Nucleic acids, found in the RNA and DNA of pathogens, contain the instructions for replication. The Mirasol PRT system causes irreversible changes to the RNA and DNA of viruses, bacteria, parasites and white blood cells, preventing them from replicating and causing disease.


How the Mirasol PRT system inactivates pathogens and white blood cells:
UV light + riboflavin = irreversible inactivation
Riboflavin molecules associate with nucleic acids of pathogens. Exposure to UV light activates riboflavin and when it is associated with pathogen nucleic acid, riboflavin causes a chemical alteration to functional groups of the nucleic acids (primarily guanine bases), making pathogens unable to replicate.

Treating platelets and plasma in three simple steps:
1. The product is transferred to the Mirasol PRT illumination/storage bag
2. Riboflavin solution is added and mixed with the product
3. The mixture is then exposed to UV light for about five to ten minutes

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